Presenilin 2 antibody-多抗-深圳欣博盛生物科技有限公司

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Presenilin 2 antibody

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX18041

规格：250μg

目录价：￥4300

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Presenilin 2 antibody

别名:

presenilin 2 , AD3L , AD4 , CMD1V , PS2 , STM2

反应种属:

Human, Mouse, Rat

宿主来源:

Chicken

实验应用:

ELISA, IHC, WB

同种型:

IgY

免疫原:

Two synthetic peptides (Human).

克隆性:

Polyclonal

克隆号:

纯化方式:

IgY fraction

偶联:

Unconjugated

产品浓度:

1 mg/ml (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

产品形式:

Liquid

生产商:

GeneTex

功能与背景:

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008]

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