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折扣/货期| 货号：AG-CR1-3667-M005 | 规格：5 mg | 目录价：￥840 |
| 货号：AG-CR1-3667-M025 | 规格：25 mg | 目录价：￥3360 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
PTACH [NCH 51]
别名:
Cpd 51; S-(7-Oxo-7-((4-phenylthiazol-2-yl)amino)heptyl) 2-methylpropanethioate
产品描述:
Potent non-hydroxamate HDAC inhibitor (HDACi) (IC50: 32, 48 and 41nM for HDAC4, HDAC1 and HDAC6, respectively). Cell permeable prodrug that is intracellularly converted to the potent HDAC inhibitor NCH 31. Predicted to exhibit a similar HDAC binding mode as that of SAHA, interacting with the active-site zinc targeting group. Shown to exhibit comparable antiproliferative and apoptotic activity as SAHA against various cancer cell lines. Inhibits growth of various cancer cells in vitro (EC50=1.1 - 9.1µM). Reactivates latent HIV-1 gene expression. Active against selected neurodevelopmental disorders.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
390.56
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>97% (HPLC)
CAS号:
848354-66-5
分子式:
C20H26N2O2S2
溶解度:
Soluble in DMSO (25mg/ml) or ethanol (10mg/ml). Insoluble in water.
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