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折扣/货期| 货号：GTX13056 | 规格：50μg | 目录价：￥5300 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
RAS antibody [Y13-259]
别名:
K-RAS Antibody , RASH1 Antibody , HAMSV Antibody , HRAS Antibody , C-HA-RAS1 Antibody , C-BAS/HAS Antibody , N-RAS Antibody , CTLO Antibody , C-H-RAS Antibody , H-RASIDX Antibody , HRAS1 Antibody , C-K-RAS Antibody , NS Antibody , KRAS1 Antibody , K-RAS4A Antibody , KRAS Antibody , KI-RAS Antibody , KRAS2 Antibody , K-RAS2B Antibody , NS3 Antibody , K-RAS2A Antibody , K-RAS4B Antibody , RASK2 Antibody , NRAS Antibody , NRAS1 Antibody , N-RAS Antibody , ALPS4 Antibody , NS6 Antibody
反应种属:
Human, Mouse, Rat
宿主来源:
Rat
实验应用:
ICC/IF, IHC-Fr, IHC-P, IP, WB
靶标/特异性:
Monoclonal Anti-vH RAS reacts with phosphorylated and non-phosphorylated forms of vH RAS and vK RAS p21's and reacts with the p21 transitional products of the H, K, and N ras human genes. It does not crossreact with Rap. This antibody neutralizes the activity of H, K, and NRas by binding to residues Glu-63, Ser-65, Ala-66, Met-67, Gln-70 and Arg-73.
同种型:
IgG
免疫原:
Recombinant full length p21 protein (Human).
克隆性:
Monoclonal
克隆号:
Y13-259
纯化方式:
Protein G purified
偶联:
Unconjugated
产品浓度:
0.1 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
50mM Sodium Phosphate, 0.2% Gelatin, 0.1% Sodium azide.
生产商:
GeneTex
功能与背景:
This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for
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