Recombinant ALK Antibody / Anaplastic Lymphoma Kinase-单抗-深圳欣博盛生物科技有限公司

首页产品中心单抗

Recombinant ALK Antibody / Anaplastic Lymphoma Kinase

品牌：NSJ Bio

官网链接

说明书

折扣/货期

货号：V3998IHC-7ML

规格：7 ml

目录价：￥6652.1

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Recombinant ALK Antibody / Anaplastic Lymphoma Kinase

产品描述:

Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK. [UniProt]

反应种属:

Human

宿主来源:

Rabbit

实验应用:

IHC-P

同种型:

Rabbit IgG, kappa

免疫原:

Recombinant full length human protein was used as the immunogen for this recombinant ALK antibody.

克隆性:

Recombinant Rabbit Monoclonal