Recombinant GTBP Antibody / G/T mismatch-binding protein / MSH6-单抗-深圳欣博盛生物科技有限公司

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Recombinant GTBP Antibody / G/T mismatch-binding protein / MSH6

品牌：NSJ Bio

官网链接

说明书

折扣/货期

货号：V5723SAF-100UG

规格：100 ug

目录价：￥6652.1

产品详情

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产品名称:

Recombinant GTBP Antibody / G/T mismatch-binding protein / MSH6

产品描述:

MSH6, also called GTBP or G/T mismatch-binding protein, is a mismatch repair protein which is deficient in a high proportion of patients with microsatellite instability (MSI-H). It has been suggested that the deficiencies in DNA mismatch repair protein(s) can be seen in some malignancies such as hereditary nonpolyposis colorectal cancer (HNPCC) and endometrial cancer. MSH6 expressed in all proliferating cells participate in repair of base-base mismatch, that occur during DNA replication. Loss of MSH6/GTBP expression leads to an accumulation of DNA replication errors in the proliferating cells, particularly in areas of the genome with short repetitive nucleotide sequences, a phenomenon known as microsatellite instability (MSI). MSH6/GTBP always used as panel with MLH1, MSH2, PMS2, and may be useful to aid in identifying the most probable gene responsible for the MSI.

反应种属:

Human

宿主来源:

Rabbit

实验应用:

IHC-P

同种型:

Rabbit IgG, kappa

免疫原:

A portion of amino acids 1-200 from human G/T mismatch-binding protein was used as the immunogen for the recombinant GTBP antibody.

克隆性:

Recombinant Rabbit Monoclonal