官网链接
折扣/货期| 货号：300-71-100UG | 规格：100 ug | 目录价：￥11979 |
| 货号：300-71-1MG | 规格：1 mg | 目录价：￥53047 |
| 货号：300-71-250UG | 规格：250 ug | 目录价：￥23150 |
| 货号：300-71-25UG | 规格：25 ug | 目录价：￥3008 |
| 货号：300-71-500UG | 规格：500 ug | 目录价：￥34409 |
| 货号：300-71-5UG | 规格：5 ug | 目录价：￥1207 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Recombinant Human GPR15L
别名:
Antimicrobial peptide-57, AP-57, Colon-derived SUSD2 binding factor, CSBF, UNQ1833/PRO3446
产品描述:
GPR15L is a newly identified ligand for GPR15, a member of the G protein-coupled receptor (GPCR) family. Upon ligation, GPR15L acts as a potent chemoattractant for GPR15-expressing T cells and together they mediate lymphocyte recruitment to the large intestine and skin. GPR15L is constitutively expressed by colon epithelial cells where its expression is minimally altered by intestinal inflammation. Conversely, GPR15L is nearly undetectable in adult epidermis but highly upregulated during wound healing and inflammation, particularly in psoriasis. Significant expression of GPR15L is also seen in additional mucosal epithelial cells, including those of the stomach, esophagus, and urinary tract. While maintaining similar expression patterns and intramolecular disulfide cysteine bridges found in members of the CC chemokine family, GPR15L differs from classic CC and CXC chemokines, whose active sites are found on the N-terminus, in that it relies on its C-terminus for receptor interaction. GPR15L was first identified as an antimicrobial peptide (AMP) due to its broad spectrum of antimicrobial activity, a property shared with many chemokines. GPR15L binds to an additional receptor, SUSD2, and early studies have indicated that both are downregulated in colon cancer tissue resulting in inhibited colon cancer growth. PeproTech's E.coli-derived Recombinant Human GPR15L consists of 57 amino acid residues and has a calculated molecular weight of 6.5 kDa.
宿主来源:
E.coli
保存温度:
Minus 20C
运输温度:
Room Temperature
产品形式:
Bulk
产地:
美国
生产商:
PeproTech
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