Recombinant Murine GPR15L-细胞因子、趋化因子与生长因子-深圳欣博盛生物科技有限公司

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Recombinant Murine GPR15L

品牌：PeproTech

官网链接

说明书

折扣/货期

货号：300-72-100UG	规格：100 ug	目录价：￥11979
货号：300-72-1MG	规格：1 mg	目录价：￥53047
货号：300-72-250UG	规格：250 ug	目录价：￥23150
货号：300-72-25UG	规格：25 ug	目录价：￥3008
货号：300-72-500UG	规格：500 ug	目录价：￥34409
货号：300-72-5UG	规格：5 ug	目录价：￥1207

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Recombinant Murine GPR15L

别名:

secreted protein C10orf99 homolog, RIKEN cDNA 2610528A11 gene, AW494830

产品描述:

GPR15L is a newly identified ligand for GPR15, a member of the G protein‐coupled receptor (GPCR) family. Upon ligation, GPR15L acts as a potent chemoattractant for GPR15‐expressing T cells and together they mediate lymphocyte recruitment to the large intestine and skin. GPR15L is constitutively expressed by colon epithelial cells where its expression is minimally altered by intestinal inflammation. Conversely, GPR15L is nearly undetectable in adult epidermis but highly upregulated during wound healing and inflammation, particularly in psoriasis. Significant expression of GPR15L is also seen in additional mucosal epithelial cells, including those of the stomach, esophagus, and urinary tract. While maintaining similar expression patterns and intramolecular disulfide cysteine bridges found in members of the CC chemokine family, GPR15L differs from classic CC and CXC chemokines, whose active sites are found on the N‐terminus, in that it relies on its C‐terminus for receptor interaction. GPR15L was first identified as an antimicrobial peptide (AMP) due to its broad spectrum of antimicrobial activity, a property shared with many chemokines. GPR15L binds to an additional receptor, SUSD2, and early studies have indicated that both are downregulated in colon cancer tissue resulting in inhibited colon cancer growth. PeproTech’s E.coli‐derived Recombinant Murine GPR15L consists of 54 amino acid residues and has a calculated molecular weight of 6.3 kDa.

宿主来源:

E.coli

保存温度:

Minus 20C

运输温度:

Room Temperature

产品形式:

Bulk

产地:

美国

生产商:

PeproTech