官网链接
折扣/货期| 货号：350-05B-100UG | 规格：100 ug | 目录价：￥17040 |
| 货号：350-05B-01M | 规格：4 x 250 ug | 目录价：￥91052 |
| 货号：350-05B-20UG | 规格：20 ug | 目录价：￥3018 |
| 货号：350-05B-250UG | 规格：250 ug | 目录价：￥40345 |
| 货号：350-05B-500 | 规格：2 x 250 ug | 目录价：￥59070 |
| 货号：350-05B-5UG | 规格：5 ug | 目录价：￥1213 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Recombinant Human IGF-BP4
别名:
Insulin-like Growth Factor-Binding Protein 4, IBP-4, HT29-IGF-BP, colon cancer cell growth inhibitor
产品描述:
IGF-BPs control the distribution, function and activity of IGFs in various cell tissues and body fluids. IGF-BP4 is the major IGF-BP produced by osteoblasts, and is found in the epidermis, ovarian follicles, and other tissues. IGF-BP4 inhibits the activity of IGF-I and IGF-II by binding in a manner that results in the formation of complexes with reduced ability to signal through cell surface IGF receptors. IGF-BP4 can inhibit the growth of chick pelvis cartilage and HT29 colon adenocarcinoma cells by blocking the mitogenic actions of IGFs, and has also been shown to reduce colony formation by colorectal cancer cells via an IGF-independent pathway. The biological effects of IGF-BP4 can be regulated by Pregnancy Associated Plasma Protein A (PAPP-A), which reduces IGF-BP4/IGF binding affinity by proteolytically cleaving IGF-BP4. The modulation of IGF-BP4 activity by PAPP-A is an important component in the regulation of ovarian folliculogenesis and in the growth inhibition of responding ovarian cancer cells. Recombinant Human IGF-BP4 is a 25.7 kDa protein consisting of 237 amino acid residues including, the IGF-BP domain and thyroglobulin type-I domain.
宿主来源:
(BTI-Tn-5B1-4) Hi-5 Insect cells
保存温度:
Minus 20C
运输温度:
Room Temperature
产品形式:
Bulk
产地:
美国
生产商:
PeproTech
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