Recombinant Human Noggin-细胞因子、趋化因子与生长因子-深圳欣博盛生物科技有限公司

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Recombinant Human Noggin

品牌：PeproTech

官网链接

说明书

折扣/货期

货号：120-10C-100UG	规格：100 ug	目录价：￥15858
货号：120-10C-01M	规格：2 x 500 ug	目录价：￥67950
货号：120-10C-20UG	规格：20 ug	目录价：￥3008
货号：120-10C-250UG	规格：250 ug	目录价：￥30121
货号：120-10C-500UG	规格：500 ug	目录价：￥44742
货号：120-10C-50UG	规格：50 ug	目录价：￥10548
货号：120-10C-5UG	规格：5 ug	目录价：￥1207

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Recombinant Human Noggin

别名:

None

产品描述:

Noggin belongs to a group of diffusible proteins that bind to ligands of the TGF-beta family, and regulate their activity by inhibiting their access to signaling receptors. The interplay between TGF-beta ligands and their natural antagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule. Noggin was originally identified as a BMP-4 antagonist whose action was critical for proper formation of the head and other dorsal structures. Consequently, noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of noggin in mice results in prenatal death, and a recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis. Recombinant Human Noggin is a 46 kDa disulfide-linked homodimer consisting of two 205 amino acid polypeptide chains. Monomeric glycosylated noggin migrates at an apparent molecular weight of approximately 28.0-33.0 kDa by SDS PAGE analysis under reducing conditions.

宿主来源:

HEK293 cells

保存温度:

Minus 20C

运输温度:

Room Temperature

产品形式:

Bulk

产地:

美国

生产商:

PeproTech