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折扣/货期| 货号：210-33R-10UG | 规格：10 ug | 目录价：￥1195 |
| 货号：210-33R-50UG | 规格：50 ug | 目录价：￥2974 |
| 货号：210-33R-100UG | 规格：100 ug | 目录价：￥16793 |
| 货号：210-33R-250UG | 规格：250 ug | 目录价：￥39759 |
| 货号：210-33R-500UG | 规格：500 ug | 目录价：￥59070 |
| 货号：210-33R-1MG | 规格：1 mg | 目录价：￥91052 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Recombinant Murine sIL-33 Receptor FC
别名:
Interleukin-33 soluble receptor Fc, Interleukin 1 receptor-like 1, Ly84, St2, Ste2
产品描述:
IL-33R, also known as ST2, is a receptor for IL-33. It is a member of the IL-1 receptor family of innate receptors. Its extracellular domain consists of 3 Ig-like domains that directly interact with its co-receptor IL-1RAcP, and the ligand alarmin, IL-33. IL-33 ligation results in the association of IL-33R complex with its adaptor proteins MyD88, IRAK1, IRAK4 and TRAF6, and activation of the NF-κB, and MAPK pathways. This, in turn, instigates the release of chemokines and cytokines such as IL-5, IL-6, IL-8, and IL-13. Two most common isoforms of IL-33R that result from alternative splicing are ST2L – the membrane bound form, and ST2S – the soluble form. The membrane bound form can be released from the cell surface by proteolytic cleavage. The soluble forms have been suggested to act as decoys dampening the IL-33 signaling. IL-33R is primarily expressed by mast cells, basophils, and eosinophils. In mice, IL-33R expression has been shown on ILC2 and Th2 cells. IL-33R signaling has been implicated in the number of immune conditions, including allergies, arthritis, atherosclerosis and sepsis. Recombinant Murine sIL-33 Receptor Fc is a 61.2 kDa protein containing 539 amino acid residues consisting of the extracellular domain of the mature sequence, as well as a 230 C-terminal Fc region linked by two glycines. As a result of glycosylation, the Recombinant Murine sIL-33 Receptor Fc migrates to an apparent molecular weight of approximately 65-75 kDa, under reducing conditions.
宿主来源:
Insect cells
保存温度:
Minus 20C
运输温度:
Room Temperature
产品形式:
Bulk
产地:
美国
生产商:
PeproTech
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