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折扣/货期| 货号：V8507-100UG | 规格：100 ug | 目录价：￥6652.1 |
| 货号：V8507-20UG | 规格：20 ug | 目录价：￥3082.1 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Recombinant PD-ECGF Antibody / Thymidine Phosphorylase
产品描述:
Recognizes a protein (amino acid 482) of 55kDa (in vivo 110kDa homodimer), identified as platelet-derived endothelial growth factor (PD-ECGF), same as thymidine phosphorylase (TP) or gliostatin. In the presence of inorganic orthophosphate, it catalyzes the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. Its enzymatic activity is crucial for angiogenic activity (metabolite is angiogenic). Higher levels of serum TP/PD-ECGF are observed in cancer patients. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites (e.g. 5-deoxy-5-fluorouridine to 5-FU). High intra-cellular levels of TP/PD-ECGF are associated with increased chemosensitivity to such antimetabolites.
反应种属:
Human
宿主来源:
Mouse
实验应用:
IHC-P, WB
同种型:
Mouse IgG1, kappa
免疫原:
Recombinant full-length human protein was used as the immunogen for the recombinant PD-ECGF antibody.
克隆性:
Recombinant Mouse Monoclonal
克隆号:
rTYMP/3444
纯化方式:
Protein G affinity chromatography
保存温度:
Store the recombinant PD-ECGF antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
产品形式:
Purified
存储溶液:
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
产地:
美国
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