Rhodopsin Antibody: ATTO 390-单抗-深圳欣博盛生物科技有限公司

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Rhodopsin Antibody: ATTO 390

品牌：Stressmarq

官网链接

说明书

折扣/货期

货号：SMC-177D-A390

规格：100 µg

目录价：￥4939.2

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Rhodopsin Antibody: ATTO 390

别名:

OPN2 Antibody, opsd Antibody, opsin 2 Antibody, opsin 2 rod pigment Antibody, opsin2 Antibody, RHO Antibody, RP4 Antibody, MGC138309 Antibody, Retinitis Pigmentosa 4 Antibody

产品描述:

Mouse Anti-Bovine Rhodopsin Monoclonal IgG1

反应种属:

Vertebrate

宿主来源:

Mouse

实验应用:

WB | IHC | ICC/IF | IP | ELISA

靶标/特异性:

Detects ~40kDa. Recognizes Rhodopsin (native and recombinant forms). No known reactivity to other proteins. Binds specifically to the C-terminal epitope -T-E-T-S-Q-V-A-P-A-(COOH).

同种型:

IgG1

推荐稀释度:

WB (1:1000), IHC (1:100); optimal dilutions for assays should be determined by the user.

免疫原:

Bovine Rhodopsin

免疫原种属:

Bovine

克隆性:

Monoclonal

克隆号:

1D4

纯化方式:

Protein G Purified

偶联:

ATTO 390

产品浓度:

1 mg/ml

保存温度:

Conjugated antibodies should be stored according to the product label

运输温度:

Blue Ice or 4ºC

存储溶液:

PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated

产地:

加拿大

功能与背景:

Rhodopsin consists of the protein moiety opsin and a reversibly covalently bound cofactor, retinal. Opsin, a bundle of seven membrane embedded alpha-helices, binds retinal, a photo reactive chromophore, in a central pocket (2, 3). In addition to being the pigment of the retina that is responsible for both the formation of the photoreceptor cells, its function is to specifically convey information stored in the specific geometry of the chormophore to the surface of the molecule upon light absorption (2). In the active state, rhodopsin activates transduction, a GTP binding protein. Once activated, transduction promotes the hydrolysis of cGMP by phosphodiesterase. Rhodopsin's activity is believed to be shut off by its phosphorylation followed by binding of the soluble protein arrestin (4). Mutations in the rhodopsin gene lead to retinitis pigmentosa, which can be inherited as an autosomal dominant, an autosomal recessive or an X-linked recessive disorder (5).

Accession #:

NP_001014890.1