深圳欣博盛生物科技有限公司 a1

RIPK1 Antibody
品牌:ProSci LLC
货号:3291-0.02 mg 规格:0.02 mg 目录价:¥1345.5
货号:3291-0.1 mg 规格:0.1 mg 目录价:¥6084
产品详情
* 以下信息仅供参考,详情请以原厂网站为准
产品名称:
RIPK1 Antibody
别名:
RIPK1 Antibody: RIP, RIP1, RIP, Cell death protein RIP, RIP-1
反应种属:
Human
宿主来源:
Rabbit
实验应用:
ELISA,IHC-P
同种型:
IgG
克隆性:
Polyclonal
纯化方式:
RIPK1 Antibody is affinity chromatography purified via peptide column.
偶联:
Unconjugated
产品浓度:
1 mg/mL
保存温度:
RIPK1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
运输温度:
Blue Ice
产品形式:
Liquid
存储溶液:
RIPK1 Antibody is supplied in PBS containing 0.02% sodium azide.
产地:
美国
生产商:
Prosci
功能与背景:
RIP1 Antibody: RIP1 (Receptor Interacting Protein), also known as RIPK1, is a crucial 74 kD adaptor kinase in several of stress-induced signaling pathways and on the crossroad of a cell's decision to live or die. RIP1 contains an N-terminal region with homology to protein kinases, an intermediate domain capable of association with MAPKKK and a C-terminal region containing a death domain motif present in the Fas and TNFR1 intracellular domains. Full length RIP1 is important for signallling to NF-kappa-B, MAPKs and necrosis, whereas caspase-8 generates a C-terminal RIP1 cleavage fragment, promoting TNF-induced apoptosis. It is required for TNFRSF1A-mediated and TLR3-induced NF-kappa-B activation. RIP1-deficient mice fail to thrive, displaying extensive apoptosis in both lymphoid and adipose tissues and dying at 1-3 days of age.
Accession #:
NP_003795
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