SARS-CoV / SARS-CoV-2 (COVID-19) spike antibody [CR3022-RB]-单抗-深圳欣博盛生物科技有限公司

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SARS-CoV / SARS-CoV-2 (COVID-19) spike antibody [CR3022-RB]

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品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX01556

规格：100μg

目录价：￥5000

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

SARS-CoV / SARS-CoV-2 (COVID-19) spike antibody [CR3022-RB]

别名:

2019-nCoV Spike , SARS-CoV-2 Spike , COVID-19 Spike

产品描述:

This antibody binds to both SARS-CoV and SARS-CoV-2 with high affinity (PMID: 16796401 & 32065055). The initial characterization of the binding of this antibody was performed by ELISA and indicates potential for the development of diagnostic assays, as both virus-capture assays, or as controls in serological assays measuring immune responses to virus exposure. The original human IgG1 version of the antibody works synergistically in combination with another non-competing SARS antibody CR3014 and is a potential candidate for passive immune prophylaxis of SARS-CoV infection (ter Meulen et al., 2006). The original antibody (human IgG1) was also reported to bind the 2019-nCoV RBD (KD of 6.3 nM). This antibody may have potential as a therapeutic agent, alone or in combination with other neutralizing antibodies for treatment of 2019-nCoV infections (Tian et al., 2020).

反应种属:

SARS Coronavirus, SARS Coronavirus 2

宿主来源:

Rabbit

实验应用:

ELISA, Neutralizing/Inhibition

靶标/特异性:

This antibody binds the amino acids 318-510 in the S1 domain of the SARS-CoV Spike protein as well as SARS-CoV-2 (COVID-19) Spike protein. The antibody also binds to P462L-substituted S318–510 fragments of the SARS spike protein. The binding epitope is only accessible in the "open" confromation of the spike protein (Joyce et al. 2020)

同种型:

IgG

免疫原:

The original monoclonal antibody was generated by sequencing peripheral blood lymphocytes of a patient exposed to the SARS-CoV.

克隆性:

Monoclonal

克隆号:

CR3022-RB

纯化方式:

Protein A purified

偶联:

Unconjugated

产品浓度:

1 mg/ml (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

产品形式:

Liquid

存储溶液:

PBS, 0.02% ProClin 300.

生产商:

GeneTex

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