SARS-CoV-2 (COVID-19) Helicase Recombinant Protein-重组病毒蛋白-深圳欣博盛生物科技有限公司

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SARS-CoV-2 (COVID-19) Helicase Recombinant Protein

品牌：ProSci LLC

官网链接

说明书

折扣/货期

货号：92-765

规格：0.05 mg

目录价：￥9038.25

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

SARS-CoV-2 (COVID-19) Helicase Recombinant Protein

别名:

SARS-CoV 2 Helicase; SARS-CoV 2 nsp13

表达系统:

E. coli

保存温度:

Store below -20˚C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.

运输温度:

Blue Ice

产品形式:

Liquid

存储溶液:

Supplied as a 0.2 um filtered solution of 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 8.5.

产地:

美国

生产商:

Prosci

功能与背景:

The non—structural protein 13 (nsp13) of SARS—CoV 2 is a helicase that separates double—stranded RNA or DNA with a 5'—3' polarity, using the energy of nucleotide hydrolysis. A basic biochemical characterization of nsp13 demonstrated that it can unwind both doublestranded DNA and RNA in a 5’-3’ direction, and it can hydrolyze all deoxyribonucleotide and ribonucleotide triphosphates. Helicases are motor proteins that utilize the energy derived from nucleotide hydrolysisto unwind double-stranded nucleic acids into two single-stranded nucleic acids. Initially, helicases were only thought to be molecular engines that unwind nucleic acids during replication, recombination, and DNA repair. Recent studies have shown that they are also involved in other biological processes, including displacement of proteins from nucleic acid, movement of Holliday junctions, chromatin remodeling, catalysis of nucleic acid conformational changes, several aspects of RNA metabolism, including transcription, mRNA splicing, mRNA export, translation, RNA stability and mitochondrial gene expression. Some human diseases, including Bloom’s syndrome, Werner’s syndrome, and Xeroderma Pigmentosum have been associated with defects in helicase function.

纯度:

Greater than 80% as determined by reducing SDS-PAGE.

Accession #:

YP_009725297.1

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