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折扣/货期| 货号：GTX79893 | 规格：100μg | 目录价：￥4700 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
SHIP1 antibody [SHIP-02]
别名:
INPP5D , SHIP , SHIP1 , SIP145 , hp51CN , inositol polyphosphate5phosphatase D , p150Ship , inositol polyphosphate-5-phosphatase D
反应种属:
Human
宿主来源:
Mouse
实验应用:
FCM, ICC/IF, WB
同种型:
IgG2a
免疫原:
Peptide coresponding to a sequence within N-terminal domain of Human SHIP-1.
克隆性:
Monoclonal
克隆号:
SHIP-02
纯化方式:
Protein A purified
偶联:
Unconjugated
产品浓度:
1 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
PBS, 15mM Sodium azide.
生产商:
GeneTex
功能与背景:
This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]
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