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折扣/货期| 货号：AG-CR1-0160-M005 | 规格：5 mg | 目录价：￥840 |
| 货号：AG-CR1-0160-M025 | 规格：25 mg | 目录价：￥2520 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Sibiriline
别名:
4-(1H-Pyrrolo[2,3-b]pyridin-2-yl)phenol
产品描述:
Specific competitive RIPK1 inhibitor in vitro (IC50=1.03µM). Binds to human RIPK1 adenosine triphosphate-binding site and locks it in an inactive conformation to block necroptosis. Necroptosis contributes to the pathogenesis of several inflammatory diseases including ischemic reperfusion injury, acute pancreatitis, sepsis, neurodegeneration, viral infection and liver diseases. Inhibits both TNF-induced RIPK1-dependent necroptosis and RIPK1-dependent apoptosis in FADD-deficient Jurkat cells (EC50=1.2µM). Does not block caspase-dependent apoptosis induced by TRAIL, FasL or staurosporine. Protects mice from concanavalin A-induced hepatitis in vivo.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
210.2
产品形式:
solid
产地:
瑞士
纯度:
>98% (HPLC)
CAS号:
1346526-26-8
分子式:
C13H10N2O
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