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折扣/货期| 货号：AG-40B-0168-3010 | 规格：3 x 10 ug | 目录价：￥2640 |
| 货号：AG-40B-0168-C010 | 规格：10 ug | 目录价：￥1320 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Slit2 (C fragment) (human) (rec.) MultiPack
别名:
Slit Homolog 2 Protein (C fragment)
产品描述:
The Slits are secreted proteins that bind to Robo receptors and play a role in axon guidance and neuronal migration. The Slit family in mice and humans comprises three members: Slit1, Slit2 and Slit3. These are all extracellular matrix proteins of 180-200kDa. In vivo, Slit2 is cleaved into 140kDa N-terminal (Slit2-N) and 55-60 kDa C-terminal (Slit2-C) fragments. Only Slit2-N and Slit2 full-length bind the Robo proteins. Recently, it has been shown that Slit2 is highly expressed in adipose tissues under the control of PRDM16 and cold exposure. Slit2 is posttranslationally cleaved by adipocytes and the resulting Slit2-C fragment improves glucose homeostasis in mice by activating a thermogenic PKA/cAMP pathway not mediated by beta-adrenergic receptors in adipocytes.
宿主来源:
HEK 293 cells
产品浓度:
0.1mg/ml after reconstitution
保存温度:
+4°C
运输温度:
BI
预期分子量:
~55kDa
产品形式:
solid
存储溶液:
Lyophilized. Contains PBS.
有效期:
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
产地:
瑞士
纯度:
>95% (SDS-PAGE)
生物活性:
Activates an UCP1-luciferase construct in mouse fat primary cells at a concentration of 20nM.
内毒素水平:
<0.01EU/µg purified protein (LAL test).
促销活动
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