TAK1 Antibody / MAP3K7-多抗-深圳欣博盛生物科技有限公司

首页产品中心多抗

TAK1 Antibody / MAP3K7

品牌：NSJ Bio

官网链接

说明书

折扣/货期

货号：F54073-0.05ML	规格：0.05 ml	目录价：￥2962.25
货号：F54073-0.2ML	规格：0.2 ml	目录价：￥6343.55

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

TAK1 Antibody / MAP3K7

产品描述:

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear factor-kappa B is activated by IKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2- induced apoptosis. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B. Promotes TRIM5 capsid-specific restriction activity. [UniProt]

反应种属:

Human, Mouse

宿主来源:

Rabbit

实验应用:

同种型:

Rabbit Ig

免疫原:

A portion of amino acids 410-444 from human TAK1 was used as the immunogen for the TAK1 antibody.

克隆性:

Polyclonal (rabbit origin)

纯化方式: