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折扣/货期| 货号：40-108-0.002 mg | 规格：0.002 mg | 目录价：￥3783 |
| 货号：40-108-0.01 mg | 规格：0.01 mg | 目录价：￥5674.5 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
TGF Beta Recombinant Protein
别名:
LDS4, TGF-beta2, Transforming growth factor beta-2, BSC-1 cell growth inhibitor, TGF-beta-2
表达系统:
(BTI-Tn-5B1-4) High-5 Insect cells
保存温度:
The lyophilized TGF Beta recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted TGF Beta is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing TGF Beta recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
运输温度:
Blue Ice
产品形式:
Lyophilized
产地:
美国
生产商:
Prosci
功能与背景:
The three mammalian isoforms of TGF-β, TGF-β1, β2, β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. TGF-β2 has been shown to exert suppressive effects on IL-2 dependent T-cell growth, and may also have an autocrine function in enhancing tumor growth by suppressing immuno-surveillance of tumor development. Recombinant human TGF-β2 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.
纯度:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
生物活性:
The ED50 was determined by its ability to inhibit the mouse IL - 4 - dependent proliferation of mouse HT - 2 cells. The ED50 was found to be ≤ 0.2 ng/mL, corresponding to a specific activity of ≥ 5 x 106 units/mg.
Accession #:
NP_001129071.1
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