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折扣/货期| 货号：CHI-HF-210TGFBM-C100 | 规格：100 ug | 目录价：￥6160 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
TGFbeta1 (mutant) (human):Fc (human) (rec.)
别名:
Transforming Growth Factor beta-1; TGFB1; TGFB
产品描述:
TGF-beta1 (Transforming growth factor beta 1) is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. In humans, TGF-beta1 is encoded by the TGFB1 gene. TGF-beta1 was first identified in human platelets as a protein with a molecular mass of 25 kaD with a potential role in wound healing. It was later characterized as a large protein precursor (containing 390 aa) that was proteolytically processed to produce a mature peptide of 112 aa. TGF-beta1 plays an important role in controlling the immune system, and shows different activities on different types of cell, or cells at different developmental stages. Most immune cells (or leukocytes) secrete TGF-beta1. Normally, TGF-beta1 is secreted as a complex with Latency-Associated Peptide (LAP) that is inactive. Removal of LAP activates TGF-beta1 that is cleared quickly from the circulation. This specific mutant protein containing the LAP+TGF-beta1 domains including the indicated three mutated cysteines, allows the protein to be active and to have long lasting biological activity with increased stability and half-life time.
宿主来源:
CHO cells
靶标/特异性:
Binds human TGFbeta. Shown to cross-react with mouse TGFbeta (see lit. reference 1).
保存温度:
+4°C
运输温度:
BI
产品形式:
solid
存储溶液:
Lyophilized from 0.2µm-filtered solution in PBS.
产地:
瑞士
纯度:
>98% (SDS-PAGE)
生物活性:
Shows the biological function of the TGFbeta1 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain.
内毒素水平:
<0.06EU/µg protein (LAL test; Lonza).
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