Thiolutin-抑制剂-深圳欣博盛生物科技有限公司

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Thiolutin

品牌：Stressmarq

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说明书

折扣/货期

货号：SIH-375-1MG

规格：1 mg

目录价：￥1584

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Thiolutin

别名:

N-(4,5-Dihydro-4-methyl-5-oxo-1,2-d¬ithiolo[4,3-b]pyrrol-6-yl)acetamide

产品描述:

RNA polymerase inhibitor

保存温度:

-20ºC

运输温度:

Shipped Ambient

预期分子量:

228.3

产品形式:

Yellow powder

产地:

加拿大

功能与背景:

Thiolutin is a sulfur antibiotic. Studies show the potential transcriptional inhibition on yeast degradation. By calculating the mRNA decay rates of transcription at different times after inhibition, it was evident that the effect of Thiolutin on the various degradation pathways of mRNA compromises the stability of the mRNA and the mechanism of gene expression (1). In pharmacology is known to inhibit endothelial cell adhesion by perturbing Hsp 27 interactions with components of the actin and intermediate filament cytoskeleton (2). Studies shown the inhibition of tumor cell-induced angionegesis in vivo, adhesion of endothelial cells to vitronectin ( IC50=0.83 µM) (3). Potentially inhibits developmental angiogenesis in zebrafish (2). Cell permeable. Active in vivo. Looking for more information on HSP27? Visit our new HSP27 Scientific Resource Guide at http://www.HSP27.com.

纯度:

≥98% (TLC); NMR (Conforms)

来源:

Synthetic

CAS号:

87-11-6

分子式:

C8H8N2O2S2

溶解度:

May be dissolved in DMSO (15 mg/ml)

PubChem CID:

6870