官网链接
折扣/货期| 货号：GTX639929 | 规格：500μl | 目录价：￥6500 |
| 货号：GTX639929-S | 规格：100μl | 目录价：￥3300 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Thymidylate synthase antibody [HMV305] HistoMAX™
别名:
thymidylate synthetase ,HST422 ,TMS ,TS
产品描述:
This antibody was validated on 76 different Normal Tissues by IHC-P.
反应种属:
Human
宿主来源:
Rabbit
实验应用:
IHC-P
靶标/特异性:
<b>Highly recommended for IHC-P in human tissues.</b>
同种型:
IgG
免疫原:
Recombinant protein encompassing a sequence within the center region of human Thymidylate synthase. The exact sequence is proprietary.
克隆性:
Monoclonal
克隆号:
HMV305
纯化方式:
Affinity purified by Protein A.
偶联:
Unconjugated
产品浓度:
0.44 mg/ml
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
PBS, 2% BSA, 0.025% ProClin 300.
生产商:
GeneTex
功能与背景:
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017]
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