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折扣/货期| 货号：34-168 | 规格：100 ug | 目录价：￥10986.3 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Thyroglobulin Antibody [SPM221]
别名:
TG, AITD3, TDH3, Thyroglobulin, TGN
反应种属:
Human,Mouse,Rat
宿主来源:
Mouse
实验应用:
Flow,IHC
同种型:
IgG1, kappa
克隆性:
Monoclonal
克隆号:
SPM221
纯化方式:
Protein G affinity chromatography
偶联:
Unconjugated
产品浓度:
0.2 mg/mL
保存温度:
Aliquot and Store at 2-8˚C. Avoid freez-thaw cycles.
运输温度:
Blue Ice
产品形式:
Liquid
存储溶液:
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
产地:
美国
生产商:
Prosci
功能与背景:
Thyroglobulin is a 660kDa dimeric pre-protein with mutiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to differentiate between primary thyroid and lung neoplasms.
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