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折扣/货期| 货号：XPS-1024 | 规格：0.1 mL | 目录价：￥9477 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Progesterone Receptor (phospho Ser294) Antibody [608]
反应种属:
Human
宿主来源:
Mouse
实验应用:
WB,IHC
靶标/特异性:
Progesterone Receptor antibody is specific for the human progesterone receptor phosphorylated at Ser294.
同种型:
IgG1
克隆性:
Monoclonal
克隆号:
608
纯化方式:
Protein G purified
偶联:
Unconjugated
产品浓度:
batch dependent
保存温度:
For long term storage –80˚C is recommended, but shorter term storage at –20˚C is also acceptable as aliquots may be taken without freeze/thawing due to the presence of 50% glycerol. Stable for one year.
运输温度:
Blue Ice
产品形式:
Liquid
产地:
美国
生产商:
Prosci
功能与背景:
There is accumulating evidence to suggest that progesterone plays an essential role in the regulation of growth and differentiation of mammary glands and thus may play a key role in breast cancer. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (A and B forms). In most cell contexts, the B form functions as a transcriptional activator, whereas the A form functions as a transcriptional inhibitor of steroid hormones. Recently it has been demonstrated that there is differential hormone dependent regulation of the phosphorylation of the A and B forms of the receptor. Treatment of T47D breast cancer cells with progestin agonist increases the phosphorylation of Ser190 and Ser294 with different kinetics. These phosphorylation events may differentially affect the transcriptional activity of the receptor.
Accession #:
P06401
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