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折扣/货期| 货号：V5688SAF-100UG | 规格：100 ug | 目录价：￥6652.1 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
TIGIT Antibody / VSTM3 / VSIG9
产品描述:
TIGIT is a checkpoint inhibitor which binds with high affinity to the poliovirus receptor (PVR), causing increased IL10 secretion, decreased IL12B secretion. TIGIT binding to PVR also causes the suppression of T cell activation by promoting the generation of mature immuno-regulatory dendritic cells. It is expressed at low levels on natural killer (NK) cells, as well as peripheral memory and regulatory CD4+ T cells. At the protein level, it is upregulated following the activation of these cells. Functionally, TIGIT is similar to CTLA4. The ligands for TIGIT include CD155 (signal abrogation) and CD226 (signal stimulation). It has been demonstrated to be upregulated on T cells in many cancers and is an immuno-oncology target for therapy.
反应种属:
Human
宿主来源:
Mouse
实验应用:
ELISA
同种型:
Mouse IgG2c, kappa
免疫原:
A portion of amino acids 22-141 from human TIGIT protein was used as the immunogen for the TIGIT antibody.
克隆性:
Monoclonal (mouse origin)
克隆号:
TIGIT/3018
纯化方式:
Protein A/G affinity
保存温度:
Aliquot the TIGIT antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
产品形式:
Purified
存储溶液:
1 mg/ml in 1X PBS; BSA free, sodium azide free
产地:
美国
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