TIGIT (human):Fc (human) (rec.)-Fc融合蛋白-深圳欣博盛生物科技有限公司

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TIGIT (human):Fc (human) (rec.)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-40B-0162-C050

规格：50 ug

目录价：￥3600

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

TIGIT (human):Fc (human) (rec.)

别名:

T Cell Immunoreceptor with Ig and ITIM Domains; V-set and Immunoglobulin Domain-containing Protein 9; V-set and Transmembrane Domain-containing Protein 3; Vstm3; VSIG9; WUCAM

产品描述:

TIGIT (T cell immunoreceptor with Ig and ITIM domains) is a novel member of the immunoglobulin super family (IgSF). TIGIT and CD226 bind the same ligands, the two nectin-family members poliovirus receptor (PVR) and poliovirus receptor-related 2 (CD112) and compete for each other. TIGIT inhibits while CD226 activates the signaling through PVR and CD112. TIGIT and CD226 directly interact at the cell surface and this interaction impairs CD226 homodimerization and function. TIGIT is absent on naive T cells, but is expressed on activated Tregs and memory T cells, and on NK cells and NKT cells. TIGIT negatively regulates T cell activation and blockade of TIGIT exacerbates several immune diseases. TIGIT also activates the PVR receptor on dendritic cells (DCs). Addition of TIGIT (human):Fc (human) to DCs triggers phosphorylation of PVR and elicits downstream signaling, which then inhibits T cell responses by producing IL-10. TIGIT also negatively regulates NK cell cytotoxicity and cytokine production. TIGIT is directly regulated by FoxP3 and promotes inducible Treg differentiation.

宿主来源:

HEK 293 cells

产品浓度:

1mg/ml after reconstitution

保存温度:

+4°C

运输温度:

预期分子量:

~40-45kDa (SDS-PAGE)

产品形式:

solid

存储溶液: