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折扣/货期| 货号：CHI-MF-110T4-C100 | 规格：100 ug | 目录价：￥6160 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Tim-4 (mouse):Fc (mouse) (rec.)
别名:
TIM4; TIMD4; T Cell Immunoglobulin and Mucin Domain-containing Protein 4
产品描述:
Mouse T cell immunoglobulin and mucin domain-containing protein 4, also known as T cell membrane protein 4, TIMD4 and TIM4 is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily and TIM family. TIM4 contains one Ig-like V-type (immunoglobulin-like) domain. It is expressed on dendritic cells and macrophages. TIM4 plays an important role in the proliferation of T helper type 2 (Th2) cells. TIM4 is involved in regulating T cell proliferation and lymphotoxin signaling. It is a ligand for HAVCR1 / TIMD1. The expression of TIM4 in fibroblasts enhanced their ability to engulf apoptotic cells. TIM4 and TIM1 are phosphatidylserine receptors for the engulfment of apoptotic cells and may also be involved in intercellular signaling in which exosomes are involved. Modulation of TIM4 production in dendritic cells (DCs) represents a novel therapeutic approach for the treatment of peanut allergy.
宿主来源:
HEK 293 cells
保存温度:
+4°C
运输温度:
BI
预期分子量:
~85kDa (SDS-PAGE)
产品形式:
solid
存储溶液:
Lyophilized from 0.2µm-filtered solution in PBS.
产地:
瑞士
纯度:
>95% (SDS-PAGE)
生物活性:
Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated human T cells.
内毒素水平:
<5EU/mg protein (LAL test; Lonza).
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