官网链接
折扣/货期| 货号：GTX28395 | 规格：50μg | 目录价：￥2400 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
TMS1 peptide
别名:
Pyd And Card Domain Containing , Asc , Card5 , Tms , Tms-1 , Tms1 , Pycard
实验应用:
Neutralizing /Inhibition
克隆号:
偶联:
Unconjugated
产品浓度:
0.20 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store the peptide at -20ºC, stable for one year.
运输温度:
dry ice
产品形式:
Liquid
存储溶液:
PBS, 0.1% BSA, 0.02% Sodium azide.
生产商:
GeneTex
功能与背景:
ASC (apoptosis-associated speck-like protein containing a CARD) or TMS 1 (target of methylation-induced silencing) is a recently identified CpG island-associated gene that becomes hypermethylated and silenced in cells overexpressing DNA cytosine-5-methyltransferase-1. TMS1 is aberrantly methylated and silenced in human breast cancer cells. Forty percent (11 of 27) of primary breast tumors exhibited aberrant methylation of ASC. Ectopic expression of ASC induced apoptosis in 293 cells and inhibited the survival of human breast cancer cells. The methylation-mediated silencing of ASC may confer a survival advantage by allowing cells to escape from apoptosis, supporting a new role for aberrant methylation in breast tumorigenesis. ASC encodes a 22-kDa predicted protein containing a COOH-terminal caspase recruitment domain (CARD). However, it is structurally unrelated to other known CARD adaptor and regulatory proteins. Ectopic expression of ASC alone was able to trigger apoptosis in 293 cells, and cell death correlated with relocalization of ASC from the cytoplasm to perinuclear, ball-like structures. Several lines of evidence support the idea that redistribution of ASC is an intermediate step in a ASC-triggered apoptotic pathway.
您可能感兴趣的产品
In vivo Collagen Hybridizing Peptide, sulfo-Cy7.5 Conjugate
货号：INVIVOKIT7.5
In vivo Collagen Hybridizing Peptide, sulfo-Cy7.5 Conjugate
货号：INVIVOCTL7.5
In vivo Collagen Hybridizing Peptide, sulfo-Cy7.5 Conjugate
货号：INVIVOTGT7.5
Collagen Hybridizing Peptide, Cy3 Conjugate
货号：RED60CTL
Collagen Hybridizing Peptide, Cy3 Conjugate
货号：RED60
Collagen Hybridizing Peptide, Cy3 Conjugate
货号：RED300
Collagen Hybridizing Peptide, Biotin Conjugate
货号：BIO60CTL
Collagen Hybridizing Peptide, Biotin Conjugate
货号：BIO60
促销活动
精品推荐
复制QQ号成功，请打开QQ后添加好友进行咨询