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折扣/货期| 货号：AG-40B-0019-3010 | 规格：3 x 10 ug | 目录价：￥4320 |
| 货号：AG-40B-0019-C010 | 规格：10 ug | 目录价：￥2160 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
TNF-alpha (human) (multimeric) (rec.) MultiPack
别名:
MultimericTNF-alpha™; ACRP30headless:TNF-alpha; ACRP30headless:TNFSF2; ACRP30headless:Tumor Necrosis Factor-alpha
产品描述:
Tumor necrosis factor (TNF, cachexin or cachectin and formerly known as tumor necrosis factor-alpha) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction. MultimericTNF-alpha™ is a high activity construct in which two trimeric TNF-alpha ligands are artificially linked via the collagen domain of ACRP30. The receptor TNF-R1 is activated by both the membrane-bound and soluble trimeric forms of TNF-alpha, whereas the receptor TNF-R2 only responds to the membrane-bound form of TNF-alpha (TNF-alpha (human) (multimeric) (rec.) (Prod. No. AG-40B-0019). Since the MultimericTNF-alpha™ mimics the membrane-bound form (forms oligomers higher than trimer), it is the only TNF-alpha protein that can activate the TNF-R2. For TNF-R1 activation, either "normal" TNF-alpha or MultimericTNF-alpha™ can be used.
宿主来源:
HEK 293 cells
靶标/特异性:
Binds to human and mouse TNF-R1 and TNF-R2.
产品浓度:
0.1mg/ml after reconstitution
保存温度:
+4°C
运输温度:
BI
预期分子量:
~34kDa (SDS-PAGE)
产品形式:
solid
存储溶液:
Lyophilized. Contains PBS.
有效期:
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
产地:
瑞士
纯度:
>95% (SDS-PAGE)
生物活性:
Activates human and mouse TNF-R1 and TNF-R2. Induces cell death at a concentration range of 0.01-10ng/ml (ED50= 0.05ng/ml or 2 x 10E7 Units/mg; WEHI 164 cells).
内毒素水平:
<0.02EU/µg purified protein (LAL test; Lonza).
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