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折扣/货期| 货号：13-266 | 规格：100 uL | 目录价：￥7423.65 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
TOP2A Antibody
别名:
TOP2A, TOP2, TP2A
反应种属:
Human,Mouse
宿主来源:
Rabbit
实验应用:
WB,IHC,IF
同种型:
IgG
克隆性:
Polyclonal
纯化方式:
Affinity purification
偶联:
Unconjugated
产品浓度:
batch dependent
保存温度:
Store at 4˚C. Avoid freeze / thaw cycles.
运输温度:
Blue Ice
产品形式:
Liquid
存储溶液:
PBS with 0.02% sodium azide, pH7.3.
产地:
美国
生产商:
Prosci
功能与背景:
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.
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