Topoisomerase II beta antibody [C3], C-term-多抗-深圳欣博盛生物科技有限公司

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Topoisomerase II beta antibody [C3], C-term

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX102640	规格：100μl	目录价：￥4000
货号：GTX102640-S	规格：25μl	目录价：￥1700

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Topoisomerase II beta antibody [C3], C-term

别名:

DNA topoisomerase II beta , TOPIIB , top2beta

反应种属:

Human, Mouse, Rat

宿主来源:

Rabbit

实验应用:

ICC/IF, IHC-P, IP, WB

同种型:

IgG

免疫原:

Recombinant protein encompassing a sequence within the C-terminus region of human Topoisomerase II beta. The exact sequence is proprietary.

克隆性:

Polyclonal

克隆号:

纯化方式:

Purified by antigen-affinity chromatography.

偶联:

Unconjugated

产品浓度:

0.48 mg/ml (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

产品形式:

Liquid

存储溶液:

PBS, 1% BSA, 20% Glycerol, 0.025% ProClin 300.

生产商:

GeneTex

功能与背景:

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing of this gene results in two transcript variants; however, the second variant has not yet been fully described. [provided by RefSeq]

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