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折扣/货期| 货号：81-602 | 规格：100 ul | 目录价：￥询价 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
TPO-R/CD110/c-Mpl Rabbit Recombinant Antibody
别名:
MPLV; TPOR; C-MPL; CD110; THPOR; THCYT2; TPO-R/CD110/c-Mpl
反应种属:
Human, Mouse, Rat
宿主来源:
Rabbit
实验应用:
WB, ELISA
同种型:
IgG
克隆性:
Monoclonal
纯化方式:
Affinity purification
偶联:
Unconjugated
产品浓度:
Batch dependent
保存温度:
Store at -20℃. Avoid freeze / thaw cycles.
运输温度:
Blue Ice
预期分子量:
80kDa
产品形式:
Liquid
存储溶液:
Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
产地:
美国
生产商:
Prosci
功能与背景:
In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.
Accession #:
P40238
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