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折扣/货期| 货号：16292-100 mg | 规格：100 mg | 目录价：￥2211 |
| 货号：16292-25 mg | 规格：25 mg | 目录价：￥1005 |
| 货号：16292-250 mg | 规格：250 mg | 目录价：￥5011.6 |
| 货号：16292-50 mg | 规格：50 mg | 目录价：￥1407 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Trametinib
别名:
GSK1120212|JTP-74057
产品描述:
An inhibitor of MEK1 and -2; inhibits B-RAF- and C-RAF-induced phosphorylation of MEK1 (IC50s = 3.4 and 1.8 nM, respectively) and MEK2 (IC50s = 1.6 and 0.92 nM, respectively); inhibits the growth of two human colorectal cancer cell lines expressing mutant B-RAF (IC50s = 0.48 and 0.52 nM) and seven cell lines expressing mutant K-Ras (IC50s = 2.2-174 nM) but does not inhibit the growth of wild-type COLO 320DM cells expressing both B-RAF and K-Ras (IC50 = >10,000 nM); reduces tumor growth in HT-29 and COLO 205 mouse xenograft models at 0.3 and 1 mg/kg per day; decreases M. tuberculosis-induced increases in hind paw volume in a rat model of arthritis at 0.03 and 0.1 mg/kg per day
保存温度:
-20
运输温度:
-20
预期分子量:
615.4
产品形式:
A crystalline solid
纯度:
≥95%
CAS号:
871700-17-3
分子式:
C26H23FIN5O4
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