TRIAD3A Antibody-多抗-深圳欣博盛生物科技有限公司

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TRIAD3A Antibody

品牌：ProSci LLC

官网链接

说明书

折扣/货期

货号：3371-0.02 mg	规格：0.02 mg	目录价：￥1345.5
货号：3371-0.1 mg	规格：0.1 mg	目录价：￥6084

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

TRIAD3A Antibody

别名:

TRIAD3A Antibody: ZIN, CAHH, U7I1, TRIAD3, UBCE7IP1, ZIN, E3 ubiquitin-protein ligase RNF216, RING finger protein 216

反应种属:

Human,Mouse

宿主来源:

Rabbit

实验应用:

ELISA,WB,IHC-P,IF

同种型:

IgG

克隆性:

Polyclonal

纯化方式:

TRIAD3A Antibody is affinity chromatography purified via peptide column.

偶联:

Unconjugated

产品浓度:

1 mg/mL

保存温度:

TRIAD3A antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

运输温度:

Blue Ice

产品形式:

Liquid

存储溶液:

TRIAD3A Antibody is supplied in PBS containing 0.02% sodium azide.

产地:

美国

生产商:

Prosci

功能与背景:

TRIAD3A Antibody: Activation of NF-κB as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses. Signals from these receptors are relayed by a number of adapter molecules such as TRIF, TIRAP, and MyD88. Several regulatory mechanisms exist to control TLR signal transduction, including the inhibition of TLR expression and signaling by molecules such as ST2 and SIGIRR. Another mechanism is by the ubi-quitinization of selected TLRs by TRIAD3A, an E3 ubiquitin-protein ligase. TRIAD3A is a RING finger protein that can bind to TLR4 and TLR9, and to a lesser extent TLR3 and TLR5, catalyzing the ubiquitization of these molecules. Overexpression of TRIAD3A promoted the nearly complete degradation of TLR4 and TLR9; this reduction was reflected in the decreased signal-specific activation by ligands specific for these TLRs. Conversely, depletion of TRIAD3A resulted in enhanced TLR activation.

Accession #:

AAP47174

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