U-0126-抑制剂-深圳欣博盛生物科技有限公司

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U-0126

品牌：Stressmarq

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说明书

折扣/货期

货号：SIH-380-5MG

规格：5 mg

目录价：￥2448

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

U-0126

别名:

1,4-Diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene

产品描述:

MEK inhibitor

保存温度:

-20ºC

运输温度:

Shipped Ambient

预期分子量:

380.5

产品形式:

White solid

产地:

加拿大

功能与背景:

U-0126 is a novel, potent and selective MEK inhibitor (MEK1; IC50=72nM, MEK2; IC50=58nM). Inhibits AP-1 transcription activity. Blocks the production of inflammatory cytokines and matrix metalloproteinases. Binding of extracellular growth factors to cell surface receptors often results in activation of the mitogen-activated protein kinase (MAPK). MAPK is regulated by MAPK kinase, also called MEK. Deprivation of growth factors during cell culture or intracellular MEK inhibition leads to inhibition of proliferation and apoptotic cell death. N Blank et al. (2002) have shown that U0126, a common used MEK inhibitor and compound that itself has no intrinsic fluorescence in vitro but develops an intensive fluorescence during cell culture which can be observed in all fluorescence channels with predominance in the FL1 channel (525nm).

纯度:

>98%

来源:

Synthetic

CAS号:

109511-58-2

分子式:

C18H16N6S2

溶解度:

Soluble in DMSO (>10 mg/ml), 100% ethanol (2 mg/ml)

PubChem CID:

3006531