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折扣/货期| 货号：AG-CR1-3698-M001 | 规格：1 mg | 目录价：￥240 |
| 货号：AG-CR1-3698-M005 | 规格：5 mg | 目录价：￥960 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
U-73122
别名:
1-[6-[[(17beta)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione
产品描述:
Gasdermin D N-terminal fragment (GSDMD-N)-induced pyroptosis inhibitor. Protects against GSDMD-N cytotoxicity in macrophages or against lethal infection in mice. Useful agent for inflammasome research. Potent cell permeable phospholipase C (PLC) , phospholipase A2 and 5-LO (5-lipoxygenase) inhibitor. Affects the phospholipases by inhibiting the hydrolysis of PPI (phosphatidylinositol) to IP3 (inositol triphosphate), which in turn leads to a drop in cytosolic Ca2+. Potent inhibitor of the SERCA pump in smooth muscle. Potently inhibits Ca2+-release from isolated smooth muscle cells independent of its effect on PLC. Inhibits agonist-induced platelet aggregation. Potently inhibits human polymorphonuclear neutrophil adhesion on biological surfaces and exhibits antinociceptive activity in vivo. Shown to inhibit agonist-induced down-regulation of muscarinic receptors in SK-N-SH neuroblastoma cells. Activates TRPM4 and inhibits TRPM3 channels. Potent human telomerase inhibitor.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
464.6
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>95%
CAS号:
112648-68-7
分子式:
C29H40N2O3
溶解度:
Soluble in methylene chloride or chloroform (10mg/ml). Slightly soluble in DMSO (2mg/ml), DMF (2mg/ml) or 100% ethanol (1mg/ml). Sparingly soluble in aqueous solutions. See also Solubility Note below.
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