UEV1A antibody-多抗-深圳欣博盛生物科技有限公司

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UEV1A antibody

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX85082

规格：100μg

目录价：￥6200

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

UEV1A antibody

别名:

ubiquitin conjugating enzyme E2 V1 , CIR1 , CROC-1 , CROC1 , UBE2V , UEV-1 , UEV1 , UEV1A

反应种属:

Human, Mouse, Rat

宿主来源:

Rabbit

实验应用:

ELISA, WB

靶标/特异性:

Anti-UEV1A may also recognize other isoforms of UEV1A.

同种型:

IgG

免疫原:

UEV1A antibody was raised against a peptide corresponding to 15 amino acids near the C-terminus of human UEV1A.The immunogen is located within the last 50 amino acids of UEV1A.

克隆性:

Polyclonal

克隆号:

纯化方式:

Purified by ion exchange chromatography

偶联:

Unconjugated

产品浓度:

1 mg/ml (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

产品形式:

Liquid

存储溶液:

PBS, 0.02% Sodium azide.

生产商:

GeneTex

功能与背景:

Ubiquitin-conjugating enzyme E2 (UEV1) was initially discovered as a protein similar in sequence and structure to the E2 ubiquitin-conjugating enzymes but lacking their enzymatic activity (1). There are at least two variants and multiple isoforms of UEV1. In particular, UEV1A (Ubiquitin-conjugating enzyme E2 variant 1 isoform A) has recently been shown to be an important component of the Toll-like receptor and IL-1R signaling pathway (reviewed in 2). Signals from these pathways are relayed by a number of downstream molecules such as MyD88 and tumor necrosis factor receptor associated factor (TRAF6), ultimately activating various kinases and transcription factors (2,3). UEV1A is part of a dimeric ubiquitin-conjugating enzyme complex also containing Ubc13 (ubiquitin-conjugating enzyme 13) that together with TRAF6 activates TAK1, a member of the mitogen-activated protein kinase kinase kinase family (4-6). The Ubc13-UEV1A complex also mediates the Lys-63 ubiquitination of TRAF-6, and this ubiquitination is essential for TAK1 activation (5).

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