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UGT1A1 Antibody

品牌：ProSci LLC

官网链接

说明书

折扣/货期

货号：15-091

规格：100 uL

目录价：￥7651.8

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

UGT1A1 Antibody

别名:

UGT1A1, GNT1, HUG-BR1, UDPGT, UGT1, UGT1A, BILIQTL1, UDPGT 1-1

反应种属:

Human,Mouse,Rat

宿主来源:

Rabbit

实验应用:

同种型:

IgG

克隆性:

Polyclonal

纯化方式:

Affinity purification

偶联:

Unconjugated

产品浓度:

batch dependent

保存温度:

Store at -20˚C. Avoid freeze / thaw cycles.

运输温度:

Blue Ice

产品形式:

Liquid

存储溶液:

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

产地:

美国

生产商:

Prosci

功能与背景:

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome.

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