VEGF 165 Recombinant Protein-细胞因子、趋化因子与生长因子-深圳欣博盛生物科技有限公司

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VEGF 165 Recombinant Protein

品牌：ProSci LLC

官网链接

说明书

折扣/货期

货号：96-773

规格：0.05 mg

目录价：￥10986.3

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

VEGF 165 Recombinant Protein

别名:

RP1-261G23.1, MGC70609, MVCD1, VEGFA, VPF, VEGF165

实验应用:

表达系统:

HEK293 cells

保存温度:

Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.

运输温度:

Blue Ice

产品形式:

Lyophilized

存储溶液:

PBS, pH7.4

产地:

美国

生产商:

Prosci

功能与背景:

VEGF165 is the most abundant splice variant of VEGF-A. VEGF165 is produced by a number of cells including endothelial cells, macrophages and T cells. VEGF165 is involved in angiogenesis, vascular endothelial cell survival, growth, migration and vascular permeability. VEGF gene expression is induced by hypoxia, inflammatory cytokines and oncogenes. VEGF165 binds to heparan sulfate and is retained on the cell surface and in the extracellular matrix. VEGF165 binds to the receptor tyrosine kinases, VEGFR1 and VEGFR2. VEGF165 is the only splice variant that binds to co-receptors NRP-1 and NRP-2 that function to enhance VEGFR2 signaling. Binding of VEGF165 to VEGFR1 and VEGFR2 leads to activation of the PI3K/AKT, p38 MAPK, FAK and paxillin. VEGF plays a key role in tumor angiogenesis in many cancers.

纯度:

>95% as determined by SDS-PAGE.

生物活性:

Immobilized Human VEGF165, His Tag at 2ug/mL (100uL/well) can bind VEGFR1/R2-Fc with a linear range of 0.1-3 ng/mL.

Accession #:

P15692-4

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