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折扣/货期| 货号：GTX52502 | 规格：50μg | 目录价：￥8000 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
VEGF165b antibody [7F17]
别名:
MVCD1 , VEGF , VEGFA , VPF , vascular endothelial growth factor A
反应种属:
Human
宿主来源:
Mouse
实验应用:
IHC-P, WB
靶标/特异性:
This antibody was selected for its ability to detect human VEGF165b. This antibody showed no cross-reactivity with rhVEGF206.
同种型:
IgG1
免疫原:
Human VEGF-165b c-terminal peptide
克隆性:
Monoclonal
克隆号:
7F17
纯化方式:
Protein G purified
偶联:
Unconjugated
产品浓度:
200 μg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
27
产品形式:
Liquid
存储溶液:
PBS, no preservatives.
生产商:
GeneTex
功能与背景:
This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. [provided by RefSeq, Nov 2015]
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