Verrucarin A-抑制剂-深圳欣博盛生物科技有限公司

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Verrucarin A

品牌：Stressmarq

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说明书

折扣/货期

货号：SIH-614-1MG

规格：1 mg

目录价：￥2419.2

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Verrucarin A

别名:

Muconomycin-A; 379-Y; Glutinosin-I; Myrothecin-I; NSC-126728

产品描述:

Modulates Amyloid-beta production in Alzheimer’s neurons

保存温度:

-20ºC

运输温度:

Shipped Ambient

预期分子量:

502.6

产品形式:

Off-white powder

产地:

加拿大

功能与背景:

Verrucarin A is a macrocyclic trichothecene mycotoxin from Myrothecium sp. It is being investigated as it modulates amyloid-beta production in Alzheimer's patients neurons (1). It is a potent and selective inhibitor of the steroid receptor coactivator-3 and selectively down-regulates its expression (2). It is cytotoxic to multiple types of cancer cells at low nM concentrations (IC50=4.9 nM for HepG2 cells) but not toward normal liver cells (2,3). It enhances TNFα-induced (4) and TRAIL-induced apoptosis (5). It reduces phosphorylation of IREα and inhibits tunicamycin-induced ER stress in FaO rat liver cells (6).

纯度:

>98% (HPLC); NMR (Conforms)

来源:

Synthetic

CAS号:

3148-09-2

分子式:

C27H34O9

溶解度:

May be dissolved in DMSO (25 mg/ml)

PubChem CID:

6326658