VISTA (human):COMP (mouse) (rec.) (His)-其他重组蛋白-深圳欣博盛生物科技有限公司

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VISTA (human):COMP (mouse) (rec.) (His)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-40B-0183-C050

规格：50 ug

目录价：￥5040

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

VISTA (human):COMP (mouse) (rec.) (His)

别名:

V-type Immunoglobulin Domain-containing Suppressor of T Cell Activation; Platelet Receptor Gi24; Stress-induced Secreted Protein-1; Sisp-1; V-set Domain-containing Immunoregulatory Receptor

产品描述:

Human VISTA is a 55 to 65kDa type I Ig membrane protein with the extracellular domain homologous to PD-L1. VISTA is mainly expressed on hematopoietic tissues (spleen, thymus and bone marrow) and on myeloid cells with lower expression on CD4+ and CD8+ T cells. VISTA is a new negative checkpoint regulator that potently suppresses T cell activation. Overexpression of VISTA on tumors inhibits the protective anti-tumor immunity and blockade of VISTA enhances antitumor immunity in multiple tumor models. VISTA on APC delivers negative signaling to T cells via a yet-to-identify binding partner on T cells. Recently, it has been reported that the recombinant VISTA protein needs to be multimerized to be active as soluble ligand. The protein VISTA (human):COMP (mouse) (with the extracellular domain of VISTA (human) fused to the pentamerization domain from the cartilage oligomeric matrix protein (COMP)), but not VISTA-Fc, functions as an immunosuppressive agonist in vivo inhibiting the proliferation of CD4+ T cells.

宿主来源:

HEK 293 cells

产品浓度:

1mg/ml after reconstitution

保存温度:

+4°C

运输温度:

预期分子量:

~40-55kDa (SDS-PAGE) and >500kDa (Size Exclusion Chromatography (SEC))

产品形式:

solid

存储溶液: