官网链接
折扣/货期| 货号：29721-1 mg | 规格：1 mg | 目录价：￥536 |
| 货号：29721-10 mg | 规格：10 mg | 目录价：￥3296 |
| 货号：29721-25 mg | 规格：25 mg | 目录价：￥6914 |
| 货号：29721-5 mg | 规格：5 mg | 目录价：￥1769 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
VLX1570
产品描述:
An inhibitor of 19S proteasomal deubiquitinases (IC50s = 6.4 and 13 μM for deubiquitinase activity in vitro using Ub-rhodamine and Ub-AMC, respectively, as substrates); selective for proteasomal deubiquitinases over a panel of deubiquitinases at 20 μM, but inhibits USP5 by >50%, and over a panel of 211 kinases at 10 μM, but inhibits Cdk4 by 77%; binds to and inhibits recombinant USP14 and UCHL5 in vitro; inhibits the USP14 and UCHL5 activity of purified 19S proteasomes at 50 μM; inhibits the proliferation of KMS-11, RPMI-8226, OPM-2, and OPM-2-BZR multiple myeloma cells (IC50s = 43, 74, 126, and 191 nM, respectively), as well as induces apoptosis and increases the accumulation of polyubiquitinated proteins; increases survival and reduces tumor growth in KMS-11-LUC2 and RPMI-8226 mouse xenograft models, respectively, at 3 mg/kg per day for 10 days
保存温度:
-20
运输温度:
-20
预期分子量:
469.394506
产品形式:
A crystalline solid
纯度:
≥98%
CAS号:
1431280-51-1
分子式:
C23H17F2N3O6
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