VSTM5 (human):Fc (human) (rec.) (non-lytic)-Fc融合蛋白-深圳欣博盛生物科技有限公司

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VSTM5 (human):Fc (human) (rec.) (non-lytic)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-40B-0237-C050

规格：50 ug

目录价：￥4800

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

VSTM5 (human):Fc (human) (rec.) (non-lytic)

别名:

V-set and Transmembrane Domain-containing Protein 5; C11orf90

产品描述:

The V-set and transmembrane domain-containing protein (VSTM) family is composed of 8 proteins: VSTM1v1, VSTM1v2, VSTM2a, VSTM2b, VSTM2L, VSTM3, VSTM4 and VSTM 5. Members of the VSTM family are associated with the regulation of functions of immune cells, adipose cells and neuronal cells. The VSTM family is an immunoglobulin (Ig) superfamily that shares structural similarities with the B7-like transmembrane proteins involved in immune regulation. VSTM1 and VSTM4 play positive and negative roles in macrophage activation, respectively. VSTM3 (TIGIT) acts as a co-inhibitory receptor that suppresses the cytokine production of T cells and NK cells. V-set and transmembrane domain-containing protein 5 (Vstm5), a newly characterized small membrane glycoprotein highly expressed in the CNS, facilitates the formation of neuronal dendrites and protrusions such as dendritic filopodia. Regulatory roles of VSTM5 for in vitro and in vivo immune responses have been reported. VSTM5 functions as a novel immune checkpoint by regulating T cell proliferation and cytokine production, Treg generation by maintenance of T cell energy and possibly induction of T cell apoptosis.

宿主来源:

HEK 293 cells

产品浓度:

1mg/ml after reconstitution.

保存温度:

+4°C

运输温度:

预期分子量:

~55kDa (SDS-PAGE)

产品形式:

solid

存储溶液: