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折扣/货期| 货号：AG-CR1-3536-M001 | 规格：1 mg | 目录价：￥240 |
| 货号：AG-CR1-3536-M005 | 规格：5 mg | 目录价：￥840 |
| 货号：AG-CR1-3536-M025 | 规格：25 mg | 目录价：￥3360 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Xamoterol hemifumarate
别名:
ICI 118587
产品描述:
A phenoxypropanolamine derivative that is a selective partial agonist of beta1-adrenergic receptors (beta1-ARs) (pA2 values are 7.4 - 7.8 and 5.2 - 6.2 at beta1- and beta2-adrenoceptors, respectively), and has shown to improve systolic and diastolic function in studies with heart failure patients. It modulates the sympathetic control of the heart but has no agonist action on beta2-adrenoceptors. Xamoterol has an EC50 value of 80nM for the generation of cyclic AMP (cAMP) in neonatal rat cardiomyocyte cultures. It increases spontaneous contraction of isolated rat right atria (EC50 = 4.67nM). In vivo, xamoterol increases heart rate, an effect that is reversed by the selective beta1-AR antagonist betaxolol but not the selective beta2-AR antagonist ICI 118551.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
339.4 . 58.0
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>98% (NMR)
CAS号:
73210-73-8
分子式:
C16H25N3O5 • 1/2C4H4O4
溶解度:
Soluble in water (20mg/ml) or DMSO (40mg/ml).
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