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折扣/货期| 货号：SIH-122-25MG | 规格：25 mg | 目录价：￥5443.2 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
YM-08
别名:
(2Z,5E)-3-ethyl-5-(3-methyl-1,3-benzothiazol-2-ylidene)-2-(pyridin-2-ylmethylidene)-1,3-thiazolidin-4-one, YM8, YM08
产品描述:
Hsp70 Inhibitor
保存温度:
-20ºC
运输温度:
Shipped Ambient
预期分子量:
367.49
产品形式:
Yellow-orange solid
产地:
加拿大
功能与背景:
YM-08 is a Heat Shock Protein 70 (Hsp70) inhibitor that is blood-brain barrier permeable. YM-08 is a neutral derivative of the Hsp70 inhibitor MKT-077. MKT-077 reduces tau levels in cellular models, but it doesn′t penetrate the blood brain barrier. Although YM-08 was somewhat less effective than MKT-077 in anti-tau and anticancer assays, it selectively reduced pathogenic tau in brain slices, which MKT-077 did not. Furthermore,YM-08 was not retained in the kidney leading one to speculate that it would not have the nephrotoxicity that was a problem for MKT-077 in clinical trials. Looking for more information on HSP70? Visit our new HSP70 Scientific Resource Guide at http://www.HSP70.com.
纯度:
>99% (HPLC)
来源:
Synthetic
CAS号:
812647-88-4
分子式:
C19H17N3OS2
溶解度:
Soluble in DMSO
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