官网链接
折扣/货期| 货号：44994-10 mg | 规格：10 mg | 目录价：￥2519 |
| 货号：44994-25 mg | 规格：25 mg | 目录价：￥5976 |
| 货号：44994-5 mg | 规格：5 mg | 目录价：￥1327 |
| 货号：44994-50 mg | 规格：50 mg | 目录价：￥9286 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Zongertinib
别名:
BI 1810631
产品描述:
An inhibitor of HER2YVMA (IC50 = 13 nM in a cellular phosphorylation assay using HEK cells); selective for the inhibition of HER2YVMA over wild-type EGFR (IC50 = 576 nM in a cellular phosphorylation assay using HEK cells); selective for HER2 over 394 kinases in a kinase inhibition assay at 1 µM but does inhibit HER4 and BMX by >80% in the same assay at the same concentration; selectively inhibits the proliferation of HER2YVMA-dependent Ba/F3 cells over those dependent on wild-type EGFR (IC50s = 16 and 1,549 nM, respectively); inhibits the proliferation of NCI H2170 cells expressing wild-type HER2 or HER2YVMA (IC50s = 6.3 and 20 nM, respectively) but not A431 cells dependent on EGFR (IC50 = >5,000 nM); reduces tumor growth in an NCI N87 HER2-amplified mouse xenograft model at 2.5-20 mg/kg twice per day
保存温度:
-20
运输温度:
-20
预期分子量:
535.612
产品形式:
A solid
纯度:
≥98%
CAS号:
2728667-27-2
分子式:
C29H29N9O2
促销活动
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