17-AAG-抑制剂-深圳欣博盛生物科技有限公司

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17-AAG

品牌：Stressmarq

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说明书

折扣/货期

货号：SIH-100A

规格：1 mg

目录价：￥1800

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

17-AAG

别名:

17-(Allylamino)-17-demethoxygeldanamycin, 17-(Allylamino)geldanamycin, 17-Demethoxy-17-allylamino geldanamycin, 17-AAG, CP 127374, Geldanamycin,17-demethoxy-17-(2-propenylamino)-, NSC 330507, Tanespimycin

产品描述:

Hsp90 inhibitor

保存温度:

-20ºC

运输温度:

Shipped Ambient

预期分子量:

585.7

产品形式:

Red to dark red powder

产地:

加拿大

功能与背景:

Glendanamycin (GA), a benzoquinone ansamycin antibiotic, interferes with the action of Hsp90 leading to degradation of Hsp90 client proteins. GA itself however has undesirable properties such as poor aqueous solubility and liver toxicity; therefore, numerous analogs have been synthesized, such as 17-AAG(1). 17-AAG is an HSP-90 inhibitor that displays a 100-fold higher affinity for HSP-90 derived from tumor cells compared to HSP-90 from normal cells(2). 17-AAG inhibits Akt activation and expression in tumors and synergizes with a number of antitumor agents such as taxol(3), cisplatin(4) and UCN-01 (400 nM 17-AAG, U937 cells)(5). It has also been found that 17-AAG is alo an effective inducer fo the autophagic pathway by which alpha synuclein can be removed. It may provide a means to modulate autophagy in neural cells (6).

纯度:

>99% (HPLC); NMR (Conforms)

来源:

Synthetic

CAS号:

75747-14-7

分子式:

C31H43N3O8

溶解度:

Soluble in DMSO (>50 mg/ml) or ethanol (5 mg/ml)

PubChem CID:

6505803