Geldanamycin-抑制剂-深圳欣博盛生物科技有限公司

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Geldanamycin

品牌：Stressmarq

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说明书

折扣/货期

货号：SIH-111A

规格：1 mg

目录价：￥1065.6

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Geldanamycin

别名:

(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

产品描述:

Hsp90 inhibitor

保存温度:

-20ºC

运输温度:

Shipped Ambient

预期分子量:

560.6

产品形式:

Yellow Solid

产地:

加拿大

功能与背景:

Glendanamycin (GA), a benzoquinone ansamycin antibiotic, interferes with the action of Hsp90 leading to degradation of Hsp90 client proteins. GA itself however has undesirable properties such as poor aqueous solubility and liver toxicity; therefore, numerous analogs have been synthesized, such as 17-AAG(1). 17-AAG is an HSP-90 inhibitor that displays a 100-fold higher affinity for HSP-90 derived from tumor cells compared to HSP-90 from normal cells(2). 17-AAG inhibits Akt activation and expression in tumors and synergizes with a number of antitumor agents such as taxol(3), cisplatin(4) and UCN-01 (400 nM 17-AAG, U937 cells)(5). Looking for more information on HSP90? Visit our new HSP90 Scientific Resource Guide at http://www.HSP90.ca.

纯度:

>95%

来源:

Produced by fermentation

CAS号:

30562-34-6

分子式:

C29H40N2O9

溶解度:

Slightly soluble in methanol, chloroform or DMSO (10 mg/ml); insoluble in water

PubChem CID:

5288382